Molecular Brain

Peripheral-central network analysis of cancer cachexia status accompanied by the polarization of hypothalamic microglia with low expression of inhibitory immune checkpoint receptors

A paper utilizing our Bacterial Flora Analysis was published by Dr. Yukari Suda, Dr. Yusuke Hamada et al., Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences.
In this paper, they investigated to demonstrate the relationship between the induction of cancer cachexia and its effects on the intestinal microbiota.
And they suggest that the release of LPS from the gut microbiota may exacerbate the inflammatory state of the hypothalamus with polarization toward microglia expressing low levels of inhibitory immune checkpoint receptors.
Our 16S rRNA Bacterial Flora Analysis was performed using mouse feces in the paper.


Int J Hematol.

Hematological malignancy
Decade-long WT1-specific CTLs induced by WT1 peptide vaccination

A paper utilizing our TCR Repertoire Analysis was published by Dr. Tatsuya Suwabe et al., Department of Hematopoietic Stem Cell Transplantation, Niigata University Medical and Dental Hospital.
In this paper, they investigated how long and to what extent WT1-specific CD8+ cytotoxic T cells (CTL) persisted after WT1 peptide vaccination, and reported that the immune response persisted for more than 10 years even after vaccination was discontinued.
Our TCR Repertoire Analysis was performed using WT1-specific CTLs after mixed lymphocyte peptide culture and revealed the diversity of WT1-specific CTLs 11 years after vaccination.


Journal for ImmunoTherapy of Cancer

Solid tumor

Dr. Kosaku Mimura in Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine has published a paper in "Journal for ImmunoTherapy of Cancer" titled "Combination of oligo-fractionated irradiation with nivolumab can induce immune modulation in gastric cancer".


Journal of Clinical Biochemistry and Nutrition

Dr. Naoko Oda in Department of clinical nutrition and Food management, Institute of Biochemical Sciences, Tokushima University Graduate School has published a paper in "Journal of Clinical Biochemistry and Nutrition" titled "Dietary phosphate disturbs of gut microbiome in mice".



Clinical immunity

Dr. Meng Ling Moi in School of International Health, Graduate School of Medicine, the University of Tokyo has published a paper in "INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES" titled "Pre-existing cross-reactive neutralizing activity against SARS-CoV-2 and seasonal coronaviruses prior to the COVID-19 pandemic (2014-2019) with limited immunity against recent emerging SARS-CoV-2 variants, Vietnam".


Current issues in molecular biology

Solid tumor

Dr. Takuro Kobayashi in Department of Urology, Graduate School of Medicine, Juntendo University, Tokyo has published a paper in "Current issues in molecular biology" titled "T-Cell Receptor Repertoire as a Predictor of Immune-Related Adverse Events in Renal Cell Carcinoma".



Solid tumor

Dr. Masami Yamauchi in Department of Gastroenterology, Graduate School of Biomedical and Health Sciences, Hiroshima University has published a paper in "COMMUNICATIONS MEDICINE" titled "Lenvatinib activates anti-tumor immunity by suppressing immunoinhibitory infiltrates in the tumor microenvironment of advanced hepatocellular carcinoma".


Science of The Total Environment

Dr. Takashi Azuma in Graduate School of Pharmaceutical Sciences, Osaka Medical and Pharmaceutical University Sciences has published a paper in "Science of The Total Environment" titled "Inactivation of antibiotic-resistant bacteria in hospital wastewater by ozone-based advanced water treatment processes".


British journal of haematology

Clinical immunity

Dr. Yohei Funakoshi in Division of Medical Oncology/Hematology, Department of Medicine, Kobe University Hospital and Graduate School of Medicine, Kobe has published a paper in "British journal of haematology" titled "Response to mRNA SARS-CoV-2 vaccination evaluated by B-cell receptor repertoire after tixagevimab/cilgavimab administration".



Basal immunity

Dr. Yukio Nakamura in Repertoire Genesis Inc. have published a paper in "Viruses" titled "Idiotope-Driven T-Cell/B-Cell Collaboration-Based T-Cell Epitope Prediction Using B-Cell Receptor Repertoire Sequences in Infectious Diseases".

In this paper, by combining two theories of immune network theory and Idiotope-driven T-B collaboration and defining the patterns of TCR-recognized epitope motifs(TREMs), we developed a T-cell epitope prediction method that identifies T-cell epitopes derived from antigen proteins by analyzing B-cell receptor (BCR) sequences. This method allowed us to identify T-cell epitopes that contain the same TREM patterns between BCR and viral antigen sequences in two different infectious diseases caused by dengue virus and SARS-CoV-2 infection. The identified epitopes were among the T-cell epitopes detected in previous studies, and T-cell stimulatory immunogenicity was confirmed. Thus, our data support this method as a powerful tool for the discovery of T-cell epitopes from BCR sequences.

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