Basal immunity
Human iPSC-derived CD4⁺ Treg-like cells engineered with chimeric antigen receptors control GvHD in a xenograft model

A paper utilizing our TCR Repertoire Analysis was published by Dr. Hisashi Yano, Shin Kaneko Laboratory, CiRA, Kyoto University.
In this paper, they report a success in producing CD4⁺ Treg-like cells derived from human iPS cells by inducing FOXP3 expression.
Using our TCR Repertoire Analysis, it was confirmed that cells cultured from non-T cell-derived iPS cells reconstitute various TCRα and β genes during their differentiation, constituting a polyclonal TCR repertoire.

Chronic ingestion of soy peptide supplementation reduces aggressive behavior and abnormal fear memory caused by juvenile social isolation

A paper utilizing our Bacterial Flora Analysis was published by Dr. Hideki Tamura, et al., Laboratory of Bifunctional Science, School of Pharmacy and Pharmaceutical Sciences, Hoshi University.
In this paper, they investigated the effects of soy peptides on the composition of the gut microbiota have been examined, suggesting that they may provide evidence that the gut microbiota influences brain function via metabolic, endocrine, immune, and neural pathways.
Our 16S rRNA Bacterial Flora Analysis was performed using mouse feces in the paper.

Peripheral-central network analysis of cancer cachexia status accompanied by the polarization of hypothalamic microglia with low expression of inhibitory immune checkpoint receptors

A paper utilizing our Bacterial Flora Analysis was published by Dr. Yukari Suda, Dr. Yusuke Hamada et al., Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences.
In this paper, they investigated to demonstrate the relationship between the induction of cancer cachexia and its effects on the intestinal microbiota.
And they suggest that the release of LPS from the gut microbiota may exacerbate the inflammatory state of the hypothalamus with polarization toward microglia expressing low levels of inhibitory immune checkpoint receptors.
Our 16S rRNA Bacterial Flora Analysis was performed using mouse feces in the paper.

Hematological malignancy
Decade-long WT1-specific CTLs induced by WT1 peptide vaccination

A paper utilizing our TCR Repertoire Analysis was published by Dr. Tatsuya Suwabe et al., Department of Hematopoietic Stem Cell Transplantation, Niigata University Medical and Dental Hospital.
In this paper, they investigated how long and to what extent WT1-specific CD8+ cytotoxic T cells (CTL) persisted after WT1 peptide vaccination, and reported that the immune response persisted for more than 10 years even after vaccination was discontinued.
Our TCR Repertoire Analysis was performed using WT1-specific CTLs after mixed lymphocyte peptide culture and revealed the diversity of WT1-specific CTLs 11 years after vaccination.

Dr. Naoko Oda in Department of clinical nutrition and Food management, Institute of Biochemical Sciences, Tokushima University Graduate School has published a paper in "Journal of Clinical Biochemistry and Nutrition" titled "Dietary phosphate disturbs of gut microbiome in mice".

Clinical immunity

Dr. Meng Ling Moi in School of International Health, Graduate School of Medicine, the University of Tokyo has published a paper in "INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES" titled "Pre-existing cross-reactive neutralizing activity against SARS-CoV-2 and seasonal coronaviruses prior to the COVID-19 pandemic (2014-2019) with limited immunity against recent emerging SARS-CoV-2 variants, Vietnam".