Publications

2016/06/13: Publication; American Society of Clinical Oncology (ASCO) 2016 Annual Meeting

New study (Junzo Hamanishi, Department of Gynecology and Obstetrics, Kyoto University, Japan) using our next generation BCR analysis revealed that B cell analysis may lead to the early response biomarker and novel anti-tumor monitoring of nivolumab treatment.

2016/03/23: Paper; Cancer Immunology Research

Hematological malignancy
Effector Regulatory T Cells Reflect the Equilibrium between Antitumor Immunity and Autoimmunity in Adult T-cell Leukemia
Cancer Immunol Res. 2016 Aug;4(8):644-9.
Department of Hematology, Respiratory Medicine and Oncology, Saga University School of Medicine
Hiroshi Ureshino
Our repertoire analysis was used in the study of leukemia. The authors isolated adult T-cell leukemia (ATL) cells expressing the cell adhesion molecule 1 (CADM1) molecule and regulatory T cells in the peripheral blood of ATL patients and performed TCR repertoire analysis. As a result, it has been reported that ATL cells expressing CADM1 express specific TCRs different from those of Treg cells. These results suggest that ATL cells and Treg cells are derived from different cell clones, although they have similar phenotypes.

2015/12/05: Publication; 57th ASH Annual Meeting & Exposition

Comprehensive T-Cell Receptor Repertoire Analysis Using Deep Sequencing and Single Cell Cloning Reveals Extreme Oligoclonality of Ex Vivo Expanded Cytomegalovirus-Reactive Cytotoxic T-Cells. The presenting author (Takahiko Miyama, Hiroshima University, Japan) has been selected for the "ASH Abstract Achievement Award."

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