Basal immunity
The R229Q mutation of Rag2 does not characterize severe immunodeficiency in mice
Sci Rep. 2019 Mar 14;9(1):4415.
Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University
Young Jin, Ara Lee
R229Q mutations in the Rag2 gene involved in TCR gene rearrangement have been identified in patients with severe combined immunodeficiency disease (SCID) and Omenn syndrome, and our repertoire analysis was used to construct a mouse model. As a result, it has been reported that the inhibition of gene rearrangement may occur due to the involvement of other factors, not just the R229Q mutation alone.

Clinical immunity
CD4⁺ T cells from patients with primary biliary cholangitis show T cell activation and differentially expressed T cell receptor repertoires
Hepatol Res. 2019 Jun;49(6):653-662.
Department of Gastroenterology and Hepatology, Jikei University School of Medicine
Ryo Nakagawa
Our TCR repertoire analysis was used in the study of primary biliary cholangitis, an autoimmune disease. As a result, it has been reported that there are different TCR repertoires in the patient group and the healthy subject group in the CD4⁺ T-cell population. In addition, the authors suggest that the CD4⁺ T-cell population in the patient population may be associated with high expression of the N-Ras gene.

Basal immunity
Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery
Nature. 2019 Jan; 565(7738):246-250.
Department of Microbiology and Immunology, Keio University School of Medicine
Minako Ito
Our TCR repertoire analysis was used in a study using a cerebral infarction model mouse. As a result of performing TCR repertoire analysis, it is reported that the accumulated T-reg cells are composed of a population different from that of the periphery. As a result, it is suggested that T-reg cells accumulating at the infarct lesion site may control nerve repair.

Basal immunity
Characterization of T cell receptors in a novel murine model of nickel-induced intraoral metal contact allergy
PLoS One. 2018 Dec 17;13(12):e0209248.
Department of Oral and Maxillofacial Surgery, School of Dental Medicine, Tsurumi University
Yasunari Nakasone
Our repertoire analysis was used in nickel allergy research. The authors created a nickel allergy mouse model and reported differences in TCR repertoire in lesions. These results suggest that activation of NKT cells and unique TCR sets may be induced in nickel allergy.

Hematological malignancy
Epstein-Barr virus-related diffuse large B-cell lymphoma in mogamulizumab-treated adult T-cell leukemia with incomplete T-cell reconstitution
Int J Hematol. 2019 Feb;109(2):221-227.
Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University
Kazuharu Kamachi
Our repertoire analysis was used in the study of leukemia. The authors performed a TCR repertoire analysis of adult T-cell leukemia (ATL) that developed EBV-related B-cell lymphoma (DLBCL) after administration of anti-CCR4 antibody (mogamulizumab). As a result, the authors reported the identification of ATL clones after treatment, decreased peripheral blood diversity, and the presence of ATL clones in skin rashes. These results suggest a link between immune abnormalities in T cells and the development of DLBCL.

Solid tumor
Induction of oligoclonal CD8 T cell responses against pulmonary metastatic cancer by a phospholipid-conjugated TLR7 agonist
PNAS. 2018 Jul 17;115(29):E6836-E6844.
Moores Cancer Center, University of California San Diego (UCSD)
Tadashi Hosoya
Our repertoire analysis was used in the study of tumor immunity. The authors report that a single dose of 1V270, a phospholipid-bound Toll-like receptor 7 (TLR7) agonist, suppresses the growth of advanced lung metastatic tumors. Furthermore, it is mentioned that the induction of tumor-specific CD8+ T cells is common in the lung and mediastinal lymph nodes. These results suggest that systemic 1V270 therapy induces tumor-specific cytotoxic T-cell responses to lung metastatic cancer, and that repertoire analysis is useful for monitoring therapeutic responses.