Solid tumor
Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis
Cell. 2018 Jun 28;174(1):88-101.e16.
Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus
Florian R. Greten
Our repertoire analysis was used in the study of tumor immunity. The authors used a TCR repertoire analysis to evaluate the association of MHC class I with the function of mitochondria and lysosomes in intestinal epithelial cells. As a result, the authors identified the diversity and individual clones of CD8⁺ T cells in the mucosa of genetically modified mice. These results suggest that treatments that induce mitophagy in intestinal epithelial cells and induce lysosomal membrane permeability may improve the balance of antitumor immunity against colorectal cancer.

Solid tumor
Quantitative T-cell repertoire analysis of peripheral blood mononuclear cells from lung cancer patients following long-term cancer peptide vaccination
Cancer Immunol Immunother. 2018 Jun;67(6):949-964.
Division of Cell Biology, Biomedical Research Center, Graduate School of Medicine, Juntendo University
Kazuyoshi Takeda
Our repertoire analysis was used in the study of peptide vaccine therapy. The authors performed a repertoire analysis of peripheral blood and tetramer-sorted peptide-specific T cells in lung cancer patients receiving peptide vaccine therapy and followed the changes over time for a long period. As a result, the authors reported that the clones were replaced depending on the treatment time, suggesting that multiple T cells respond to the treatment.

Hematological malignancy
Next-Generation Immune Repertoire Sequencing as a Clue to Elucidate the Landscape of Immune Modulation by Host-Gut Microbiome Interactions
Front Immunol. 2018 Apr 3;9:668.
Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine (RIRBM), Hiroshima University
Tatsuo Ichinohe
Our repertoire analysis was used in the study of blood tomors. The authors have identified cytomegalovirus pp65-specific TCR clones using TCR repertoire analysis. In addition, the authors evaluated the relationship between gut microbiota and repertoire, suggesting that the accumulation of more information could be an approach to immune-related diseases and immune homeostasis.

Solid tumor
IL-7 and CCL19 expression in CAR-T cells improves immune cell infiltration and CAR-T cell survival in the tumor
Nat Biotechnol. 2018 Apr;36(4):346-351.
Department of Immunology, Yamaguchi University Graduate School of Medicine
Koji Tamada
Our repertoire analysis was used in the study of chimeric antigen receptor (CAR)-expressing T cells. The authors performed a TCR repertoire analysis on CAR-T cells that co-produce IL7 and CCL19 and compared their TCR diversity. As a result, CAR-negative T cells in mice in which cancer cells were eliminated had lower TCR diversity than before transfer, and CAR-positive T cells became a biased TCR repertoire after memory formation. These results suggest that TCR repertoire analysis may help demonstrate tumor antigen-specific memory formation and epitope spreading on tumor antigens.

Basal immunity
Increased diversity with reduced "diversity evenness" of tumor infiltrating T-cells for the successful cancer immunotherapy
Sci Rep. 2018 Jan 18;8(1):1058.
Department of Immunotherapeutics, The University of Tokyo Hospital
Akihiro Hosoi
Our repertoire analysis was used in research on immune checkpoint inhibitors (ICI). The authors evaluated TCR repertoire analysis of T cells infiltrating tumor tissue in B16 melanoma mice treated with multiple ICIs. As a result, the diversity and tendency of repertoire changed depending on the drug. These results suggest that repertoire analysis may be a biomarker for assessing immune-related adverse events in immunotherapy.

Hematological malignancy
Escape from thymic deletion and anti-leukemic effects of T cells specific for hematopoietic cell-restricted antigen
Nat Commun. 2018 Jan 15;9(1):225.
Interdisciplinary Graduate Program in Genetic Engineering, Seoul National University
Eun Young Choi
Our repertoire analysis was used in the study of leukemia. The authors performed a TCR repertoire analysis using different mouse strains and reported that T cells that recognize antigens that are restrictive to hematopoietic cells avoid negative selection in the thymus. These results suggest that these cells have an antitumor effect during bone marrow transplantation.

Basal immunity
Possible involvement of invariant natural killer T cells and mucosal-associated invariant T cells in a murine model of titanium allergy
J Oral Maxillofac Surg Med Pathol. 2018 Jan;30(1):1-9.
Department of Oral and Maxillofacial Surgery, School of Dental Medicine, Tsurumi University
Kenichi Kumagai
Our repertoire analysis was used in titanium allergy research. The authors created a titanium allergy mouse model and reported the difference in TCR repertoire in lesions. These results suggest that activation of NKT cells and MAIT cells (mucosa-related invariant T cells) may be induced in titanium allergy.

Hematological malignancy
Deep sequencing of the T cell receptor visualizes reconstitution of T cell immunity in mogamulizumab-treated adult T cell leukemia
Oncoimmunology. 2017 Dec 11;7(3):e1405204.
Department of Hematology/Oncology, Kyoto University Graduate School of Medicine
Takero Shindo
Our repertoire analysis was used in the study of leukemia. The authors performed a TCR repertoire analysis in patients with adult T-cell leukemia (ATL) and reported changes in blood and skin TCR repertoire when mogamulizumab, a specific treatment, was used. As a result, it was found that the magnitude of ATL cells in blood was specifically changed by using mogamulizumab.