Clinical immunity
Skewing of the B cell receptor repertoire in myalgic encephalomyelitis/chronic fatigue syndrome
Brain Behav Immun. 2021 Jul;95:245-255.
Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP)
Wakiro Sato
In this study, researchers performed an analysis using lymphocytes in the peripheral blood of patients with myopathic encephalomyelitis/chronic fatigue syndrome (ME/CFS,) and discovered new immune abnormalities from the analysis results, which is useful for diagnosis. It was reported that it could be a good blood diagnostic marker. Our BCR repertoire analysis was used, and our researchers are also participating in the research as co-authors of the paper. From the analysis results, we found that specific BCRs are increased in the patient group and that this analysis method is also useful as a diagnostic marker. The results of this research will lead to an understanding of the relationship between infection and immune pathology in ME/CFS and are expected to be applied to the establishment of objective diagnostic methods for ME/CFS and the development of therapy.

Clinical immunity
Autoreactivity of Peripheral Helper T Cells in the Joints of Rheumatoid Arthritis
J Immunol. 2021 May 1;206(9):2045-2051.
Department of Orthopedic Surgery, Kyushu University
Takahide Sakuragi
Our TCR repertoire analysis was used in a study to explore the PDGFR + gp38 + DPP4-thymic fibroblast subset required to induce T-cell tolerance. Mouse TCR repertoire analysis shows that the selection of some TCR clones can be avoided by deleting a specific LTβR.

Solid tumor
Clinical significance of peripheral TCR and BCR repertoire diversity in EGFR/ALK wild-type NSCLC treated with anti-PD-1 antibody
Cancer Immunol Immunother. 2021 Oct;70(10):2881-2892.
Department of Thoracic Oncology, Kanagawa Cancer Center
Yoshiro Nakahara
The authors conducted TCR/BCR repertoire analysis from peripheral blood before and after administration of anti-PD-1 antibody to patients with EGFR/ALK gene mutant non-small cell lung cancer and investigated the therapeutic effect and diversity.

Solid tumor
Enhanced humoral immunity in breast cancer patients with high serum concentration of anti‐HER2 autoantibody
Cancer Med. 2021 Feb;10(4):1418-1430.
Department of Breast and Endocrine Surgery, Osaka University Graduate School of Medicine
Yasufumi Sato
The authors are investigating how humoral immunity is involved in patients with high and low levels of anti-HER2 antibody, which is known to play an important role in controlling breast cancer. As a result, it was reported that humoral immunity in the tumor microenvironment was enhanced in the group of patients with high anti-HER2 antibody levels. Repertoire analysis of tumor-infiltrating B cells has been performed to examine the differences in the diversity of tumor-infiltrating B cells between the high and low HER2 antibody groups.

Solid tumor
Clonal Expansion of Tumor-Infiltrating T Cells and Analysis of the Tumor Microenvironment within Esophageal Squamous Cell Carcinoma Relapsed after Definitive Chemoradiation Therapy
Int J Mol Sci. 2021 Jan 22;22(3):1098.
Departments of Clinical Oncology and Gastroenterological Surgery, National Hospital Organization Sagamihara National Hospital
Takahiro Mori
The paper explores the involvement of T-cell clone proliferation in the prognosis of surgical treatment of patients with esophageal cancer and combined radiochemotherapy after resection. TCR repertoire analysis shows that T-cell clonal diversity of tumor-infiltrating lymphocytes decreases after treatment.

Basal immunity
A clinically applicable and scalable method to regenerate T-cells from iPSCs for off-the-shelf T-cell immunotherapy
Nat Commun. 2021 Jan 18;12(1):430.
Shin Kaneko Laboratory, Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University
Shoichi Iriguchi
The authors have developed a method to obtain a large number of T cells without using feeder cells, and have confirmed using our technology that the created iPS-derived T cells are regenerating the original T cells. It is expected that the mass production of medical T cells using iPS cells will contribute to the development of research on human T-cell differentiation.