A paper on a method for evaluating immune response to SARS-CoV-2 vaccine using BCR repertoire analysis has been published in the online edition of the British journal of haematology.
Dr. Yohei Funakoshi in Kobe University Graduate School of Medicine has reported his research on a method for evaluating immune response to SARS-CoV-2 vaccine using BCR Repertoire analysis in "British journal of haematology".
In this paper, they performed BCR repertoire analysis after mRNA vaccination in patients treated with recombinant SARS-CoV-2-specific antibody drug that cannot be evaluated by conventional serological tests, and reported a method for quantifying SARS-CoV-2-specific antibodies at the mRNA level by matching antibody gene sequences with the SARS-CoV-2 specific antibody database.
This method can be applied to the evaluation of various viral infections and vaccines, and can also be used to determine neutralization/non-neutralization, or specificity to a virus strain.
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